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The Center for Fertility and Gynecology

Preimplantation Genetic Diagnosis

Description

Preimplantation genetic diagnosis is a process of selecting the embryo that is most likely to result in a successful pregnancy through IVF. We can identify any chromosomal defects in your embryos during a sophisticated screening process. It can be performed both in fresh embryo transfers and those involving frozen embryos.

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The pre-implantation genetic diagnosis is a method how we try to select embryos to transfer. We know that not every embryo is going to implant. The goal is to select and find the best embryo that will help the patient conceive, ideally, the first time. We also prefer to transfer only one whenever we can. The goal is always to have a singleton and not multiple. And the method, we know that about 50% to 80% of all embryos aren't going to have chromosomal defects. By identifying those before we transfer them back, we are able to select the best embryo that can be transferred back into the patient and this way give her the best possible chances to conceive, ideally, the very first time and, ideally, with a single embryo. What the patient does not see is what happens in the laboratory once we obtain the eggs, once the embryo is created in a laboratory. There is a lot of work happening behind the scenes to analyze those. There are different laboratory methods that we can employ to analyze the chromosomes in the embryo. It used to be a more simple method with using fluorescent dyes and using a microscope. That evolved to an array CGH, which is a more advanced method. However, most recently, we have the next-gen sequencing, which does allow us to sequence the embryo to a much higher accuracy where we can provide the patient with results overnight. So the goal is to biopsy the embryo one day, run the sequencing overnight and then transfer the next day if the patient desires a fresh embryo transfer. There are some patients that might benefit from freezing the embryo before placing it back into the patient. We are happy that we can offer the most advanced treatment just evolved in the last couple of years. We can offer that laboratory technique overnight. We can do fresh transfers with next-gen sequencing. We prefer to biopsy the embryos on day five and transfer them on day six. Chinese Transcripts: 植入前遗传诊断是我们用于选择胚胎实施转移的一种方法。我们知道并不是每个胚胎都可以植入。我们的目标是选择和找到最好的胚胎。这将有助于患者受孕,最好是一次受孕。我们也尽可能一次转移成功。 目标通常是一个胚胎,而不是多个胚胎。关于该方法,我们了解大约 50% 至 80% 的胚胎都不会有染色体缺陷。通过转移胚胎前确定染色体缺陷,我们能够选择可以转移回患者体内的最佳胚胎,并且以这种方式使患者受孕,最好一次受孕一个胚胎。一旦我们获得卵子并且在实验室中创造胚胎,患者不会看到在实验室实施的工作。其实幕后有很多分析工作。 我们可以使用多种实验室方法分析胚胎中的染色体。原来使用较简单的方法,即荧光染料和显微镜。目前已演变为微阵列比较基因组杂交技术,这是一种更先进的方法。但是,我们最近使用下一代测序方法。该方法使我们能够以更高的精度检测胚胎染色体序列,并且隔夜就可以向患者提供结果。 因此,如果患者希望移植新鲜的胚胎,我们的目标是一天内实施胚胎活检,隔夜完成测序,然后第二天移植胚胎。有些患者可能在将胚胎植入体内前冻结胚胎。我们很高兴能够提供最近几年研发取得的最先进治疗方法。我们可以提供隔夜实验室技术。我们可以使用下一代测序法移植新鲜胚胎。我们倾向于在第五天对胚胎实施活检,在第六天移植胚胎。

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