Recurrent Pregnancy Loss Doctors Can Enhance Your Chances for Successful Treatment

woman with recurrent pregnancy lossPregnancy loss can be one of the most difficult experiences of a woman’s life.  Fortunately for most women, a single miscarriage does not increase the chance of having another pregnancy loss in the future.  Some women however, suffer multiple miscarriages; this scenario is termed recurrent pregnancy loss (RPL).  

By strict definition, recurrent pregnancy loss is 3 consecutive miscarriages which occur before 20 weeks gestation.  In reality, many women with 2 consecutive losses or those with 2-3 non-consecutive losses often seek evaluation and treatment.

The causes of recurrent pregnancy loss can be divided into 4 main categories and each category requires its own specific tests and treatment.  Depending on a patient's specific history and physical, some tests and treatments may be more pertinent than others.


Anatomic causes for RPL include congenital abnormalities of the uterus such as uterine septum as well as acquired uterine abnormalities such as scarring or fibroids.  Anatomic causes may be evaluated by a variety of imaging tests such as HSG, ultrasound, MRI and more.  Ultimately, surgery may be able to correct the anatomic abnormality and prevent future losses.


Genetic causes of RPL can originate in the mother’s DNA, the father’s DNA or both.  Highly specialized and advanced tests may be used to evaluate that DNA through a simple blood sample.  Ultimately, if the DNA is implicated in the RPL, IVF can be employed to create embryos which are then evaluated for the abnormality prior to placement in the uterus.  The embryo evaluation is performed using PGT-M (PGD).

Immune/ Hormonal/ Clotting

The hormonal and immune and thrombotic environment during gestation is critically important to successful a pregnancy.  While some factors associated with immunity or blood clots are clearly associated with RPL (antiphospholipid antibodies for example), other factors (natural killer cells) have considerably weaker scientifically based connections.  With that being said, our doctors are experts at choosing which tests to order and not order to best evaluate for this type of pregnancy loss.  Once the cause is established, a variety of treatments are available.


Despite the vast array of tests available, about 1/3rd of all cases of RPL remain unexplained.  While we may not ever elucidate the cause, this does not prevent us from taking specific empiric measures to improve the chance for successful pregnancy.  Depending on a patient’s history, basic medications such as aspirin and progesterone plus frequent monitoring have been shown to improve outcomes.  In other cases, injections, infusions or PGT-M (PGD) may also be used.

Recurrent pregnancy is devastating.  At our center, we believe that the combination of appropriate testing, aggressive and creative treatment plus compassionate care can lead to success in even the most dire circumstances.  If you have questions about recurrent loss, please contact us, we will be happy to speak with you.


The Center for Fertility and Gynecology

The Center for Fertility and Gynecology provides cutting-edge medical care in a patient-oriented and supportive setting. Drs. Michael Vermesh and Tannaz Toloubeydokhti offer all couples the best possible evaluation, diagnosis, and treatment of male and female infertility. Our experienced physicians are affiliated with:

  • American Association of Gynecologic Laparoscopists
  • ACOG: American College of Obstetricians and Gynecologists
  • American Medical Association
  • ASRM: American Society for Reproductive Medicine
  • Pacific Coast Reproductive Society
  • Resolve: The National Infertility Association
  • SREI: Society for Reproductive Endocrinology and Infertility
  • The Seed Fertility Program

Ready to start your family? Request your consultation today by filling out our online form or calling (818) 881-9800.

Get In Touch

Rate, Review & Explore

Social Accounts Sprite
Google map image of our location in 18370 Burbank Blvd Ste 301 Tarzana, CA

Tarzana Office

18370 Burbank Blvd
Ste 301
Tarzana, CA 91356

Open Today

Google map image of our location in 5353 Balboa Blvd Ste 301 Encino, CA

Our Lab

5353 Balboa Blvd
Ste 301
Encino, CA 91316

Closed Today

Google map image of our location in 9610 Stockdale Hwy  Bakersfield, CA

Bakersfield Office

9610 Stockdale Hwy
Bakersfield, CA 93311

Closed Today

Google map image of our location in 24241 Hawthorne Blvd Ste 201 Torrance, CA

Torrance Office

24241 Hawthorne Blvd
Ste 201
Torrance, CA 90505

Open Today

Google map image of our location in 415 Rolling Oaks Dr  Thousand Oaks, CA

Thousand Oaks Office

415 Rolling Oaks Dr
Thousand Oaks, CA 91361

Closed Today

Tell us a bit about yourself...

(818) 881-9800 Send a message